产品名称
RILP Rabbit Polyclonal Antibody
蛋白名称
Rab-interacting lysosomal protein
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96NA2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96NA2/entry
Mouse Swissprot No.
Q5ND29
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q5ND29
免疫原
Synthesized peptide derived from human protein . at AA range: 70-150
特异性
RILP Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Rab interacting lysosomal protein(RILP) Homo sapiens This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011],
组织表达
Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain.
细胞定位
Late endosome membrane . Lysosome membrane . Cytoplasmic vesicle, phagosome membrane . Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes. .
功能
function:Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.,similarity:Contains 1 RILP-like domain.,subcellular location:Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7 is necessary for its recruitment to phagosomes.,subunit:Homodimer. Each subunit can interact with either RAB7 or RAB34.,tissue specificity:Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
