产品名称
MAP1S Rabbit Polyclonal Antibody
基因名称
MAP1S BPY2IP1 C19orf5 MAP8 VCY2IP1
蛋白名称
Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55201
Human Swissprot No.
Q66K74
Human Swissprot Link
https://www.uniprot.org/uniprot/Q66K74
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=270058
Mouse Swissprot No.
Q8C052
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C052/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=290640
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P0C5W1/entry
特异性
This antibody detects endogenous levels of MAP1S at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine, spleen and stomach. Weakly expressed in muscle.
细胞定位
Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules. .
功能
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).
