产品名称
PELO Rabbit Polyclonal Antibody
蛋白名称
Protein pelota homolog (EC 3.1.-.-)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53918
Human Swissprot No.
Q9BRX2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BRX2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=105083
Mouse Swissprot No.
Q80X73
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80X73/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=294754
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XIP1/entry
特异性
This antibody detects endogenous levels of PELO at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed.
细胞定位
Nucleus . Cytoplasm .
功能
Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway . In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes . Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway . As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy .
