产品名称
TMOD1 Rabbit Polyclonal Antibody
蛋白名称
Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7111
Human Swissprot No.
P28289
Human Swissprot Link
https://www.uniprot.org/uniprot/P28289
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21916
Mouse Swissprot No.
P49813
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P49813/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P70567/entry
特异性
This antibody detects endogenous levels of TMOD1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in the erythrocyte, heart and skeletal muscle.
细胞定位
Cytoplasm, cytoskeleton . In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). .
功能
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
