产品名称
HELLS Rabbit Polyclonal Antibody
基因名称
HELLS PASG SMARCA6 Nbla10143
蛋白名称
Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3070
Human Swissprot No.
Q9NRZ9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NRZ9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15201
Mouse Swissprot No.
Q60848
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60848/entry
特异性
This antibody detects endogenous levels of HELLS at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias.
细胞定位
Nucleus . Closely associated with pericentric heterochromatin. .
功能
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).
