产品名称
PIH1D1 Rabbit Polyclonal Antibody
蛋白名称
PIH1 domain-containing protein 1 (Nucleolar protein 17 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55011
Human Swissprot No.
Q9NWS0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NWS0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68845
Mouse Swissprot No.
Q9CQJ2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQJ2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=292898
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4V7F5/entry
特异性
This antibody detects endogenous levels of PIH1D1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed at low levels in normal mammary epithelial cells (at protein level) (PubMed:24036451). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus (PubMed:21078300).
功能
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles . Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription . Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 . Positively regulates the assembly and activity of the mTORC1 complex .
