产品名称
PSMC2 Rabbit Polyclonal Antibody
蛋白名称
26S protease regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) (Protein MSS1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5701
Human Swissprot No.
P35998
Human Swissprot Link
https://www.uniprot.org/uniprot/P35998
Mouse Swissprot No.
P46471
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P46471/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25581
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63347/entry
特异性
This antibody detects endogenous levels of PSMC2 at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Colocalizes with TRIM5 in cytoplasmic bodies. .
功能
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
