产品名称
KPTN Rabbit Polyclonal Antibody
蛋白名称
Kaptin (Actin-associated protein 2E4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11133
Human Swissprot No.
Q9Y664
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y664
Mouse Swissprot No.
Q8VCX6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VCX6/entry
特异性
This antibody detects endogenous levels of KPTN at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Lysosome membrane . Cell projection, lamellipodium . Cell projection, stereocilium . Localization to lysosomes is amino acid-independent (PubMed:28199306). Colocalizes with F-actin (PubMed:24239382). .
功能
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
