产品名称
VPS39 Rabbit Polyclonal Antibody
基因名称
VPS39 KIAA0770 TLP VAM6
蛋白名称
Vam6/Vps39-like protein (TRAP1-like protein;) (hVam6p)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23339
Human Swissprot No.
Q96JC1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96JC1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=269338
Mouse Swissprot No.
Q8R5L3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R5L3/entry
特异性
This antibody detects endogenous levels of VPS39 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain, placenta and spleen.
细胞定位
Cytoplasm. Lysosome membrane ; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein . Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles. .; (Microbial infection) Sequestrated at the late endosome by SARS coronavirus-2/SARS-CoV-2 ORF3A protein. .
功能
Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. ; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes . Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes . Required for fusion of endosomes and autophagosomes with lysosomes .
