产品名称
TMEM175 Rabbit Polyclonal Antibody
蛋白名称
Transmembrane protein 175
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84286
Human Swissprot No.
Q9BSA9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BSA9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72392
Mouse Swissprot No.
Q9CXY1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CXY1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=305623
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AY05/entry
特异性
This antibody detects endogenous levels of TMEM175 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein .
功能
Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes . Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion . Constitutes the major lysosomal potassium channel . Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors . The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation . The lysoK(GF) complex is required to protect neurons against stress-induced damage .
