产品名称
TRIM29 Rabbit Polyclonal Antibody
蛋白名称
Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23650
Human Swissprot No.
Q14134
Human Swissprot Link
https://www.uniprot.org/uniprot/Q14134
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72169
Mouse Swissprot No.
Q8R2Q0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R2Q0/entry
特异性
This antibody detects endogenous levels of TRIM29 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in placenta, prostate and thymus.
细胞定位
Cytoplasm . Lysosome . Colocalizes with intermediate filaments.
功能
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
