产品名称
ARHGAP10 Rabbit Polyclonal Antibody
蛋白名称
Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79658
Human Swissprot No.
A1A4S6
Human Swissprot Link
https://www.uniprot.org/uniprot/A1A4S6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=78514
Mouse Swissprot No.
Q6Y5D8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6Y5D8/entry
特异性
This antibody detects endogenous levels of ARHGAP10 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
High levels of expression in heart and skeletal muscle.
细胞定位
Cytoplasm . Cytoplasm, perinuclear region . Cell membrane . Association to cell membrane is dependent on PH domain. .
功能
GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
