产品名称
IRF8 Rabbit Polyclonal Antibody
蛋白名称
Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3394
Human Swissprot No.
Q02556
Human Swissprot Link
https://www.uniprot.org/uniprot/Q02556
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15900
Mouse Swissprot No.
P23611
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P23611/entry
特异性
This antibody detects endogenous levels of IRF8 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Predominantly expressed in lymphoid tissues.
细胞定位
Nucleus . Cytoplasm . In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction. .
功能
Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) . Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells .
