产品名称
LAPTM4B Rabbit Polyclonal Antibody
蛋白名称
Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55353
Human Swissprot No.
Q86VI4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q86VI4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114128
Mouse Swissprot No.
Q91XQ6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91XQ6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=315047
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U1W4/entry
特异性
This antibody detects endogenous levels of LAPTM4B at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endomembrane system ; Multi-pass membrane protein . Late endosome membrane . Cell membrane . Cell projection . Lysosome membrane . Endosome membrane. Endosome, multivesicular body membrane . Endosome, multivesicular body lumen .
功能
Required for optimal lysosomal function . Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation . Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation . Plays a role as negative regulator of TGFB1 production in regulatory T cells . Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways .
