产品名称
STRA6 Rabbit Polyclonal Antibody
基因名称
STRA6 PP14296 UNQ3126/PRO10282/PRO19578
蛋白名称
Stimulated by retinoic acid gene 6 protein homolog
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64220
Human Swissprot No.
Q9BX79
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BX79
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20897
Mouse Swissprot No.
O70491
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O70491/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363071
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4QR83/entry
特异性
This antibody detects endogenous levels of STRA6 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris.
细胞定位
Cell membrane ; Multi-pass membrane protein . In the retinal pigment epithelium localizes to the basolateral membrane. .
功能
Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 . Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A . Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin . Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid . STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid .
