产品名称
MCRS1 Rabbit Polyclonal Antibody
蛋白名称
Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10445
Human Swissprot No.
Q96EZ8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96EZ8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51812
Mouse Swissprot No.
Q99L90
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99L90/entry
特异性
This antibody detects endogenous levels of MCRS1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.
细胞定位
Nucleus . Nucleus, nucleolus . Cytoplasm . In microspherules in the nucleolus. .
功能
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus . As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues . Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity . Binds to G-quadruplex structures in mRNA . Binds to RNA homomer poly(G) and poly(U) .
