产品名称
ATAD3A/B Rabbit Polyclonal Antibody
基因名称
ATAD3B KIAA1273 TOB3
蛋白名称
ATPase family AAA domain-containing protein 3B (AAA-TOB3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83858
Human Swissprot No.
Q5T9A4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5T9A4
特异性
This antibody detects endogenous levels of ATAD3A/B at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Tends to be down-regulated in differentiated cells and re-expressed in pluripotent stem cells or cancer cells (at protein level).
细胞定位
Mitochondrion inner membrane ; Peripheral membrane protein . Has been found to co-purify with nucleoids (PubMed:22453275). Since it does not face the mitochondrial matrix, the association with nucleoids could be mediated by ATAD3A. .
功能
May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.
