产品名称
WDR19/IFT144 Rabbit Polyclonal Antibody
蛋白名称
WD repeat-containing protein 19
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57728
Human Swissprot No.
Q8NEZ3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NEZ3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=213081
Mouse Swissprot No.
Q3UGF1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UGF1/entry
特异性
This antibody detects endogenous levels of WDR19/IFT144 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Some isoforms are tissue-specific. Highly expressed in the prostate. Lower expression in the cerebellum, pituitary gland, fetal lung, and pancreas. In normal prostate, expressed in both basal and luminal epithelial cells. No expression detected in fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes. Uniformed expression in prostate adenocarcinoma cells.
细胞定位
Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Cell projection, cilium, photoreceptor outer segment . Localizes to photoreceptor connecting cilia, to the base of motile cilia in brain ependymal cells and to the base of and along primary cilia in kidney cells. .
功能
As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly . Essential for functional IFT-A assembly and ciliary entry of GPCRs . Associates with the BBSome complex to mediate ciliary transport (By similarity).
