产品名称
RPN1 Rabbit Polyclonal Antibody
蛋白名称
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (EC 2.4.1.119) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6184
Human Swissprot No.
P04843
Human Swissprot Link
https://www.uniprot.org/uniprot/P04843
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=103963
Mouse Swissprot No.
Q91YQ5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91YQ5/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25596
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P07153/entry
特异性
This antibody detects endogenous levels of RPN1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in all tissues tested.
细胞定位
Endoplasmic reticulum . Endoplasmic reticulum membrane; Single-pass type I membrane protein . Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
功能
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation . N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
