产品名称
DNAJA1 Rabbit Polyclonal Antibody
基因名称
DNAJA1 DNAJ2 HDJ2 HSJ2 HSPF4
蛋白名称
DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3301
Human Swissprot No.
P31689
Human Swissprot Link
https://www.uniprot.org/uniprot/P31689
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15502
Mouse Swissprot No.
P63037
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P63037/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65028
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P63036/entry
特异性
This antibody detects endogenous levels of DNAJA1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver.
细胞定位
Membrane ; Lipid-anchor . Cytoplasm . Microsome . Nucleus . Cytoplasm, perinuclear region . Mitochondrion . Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. .
功能
Co-chaperone for HSPA8/Hsc70 . Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) . Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis . Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV .
