产品名称
WAPL; WAPAL Rabbit Polyclonal Antibody
基因名称
WAPAL FOE KIAA0261 WAPL
蛋白名称
Wings apart-like protein homolog (Friend of EBNA2 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23063
Human Swissprot No.
Q7Z5K2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q7Z5K2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=218914
Mouse Swissprot No.
Q65Z40
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q65Z40/entry
特异性
This antibody detects endogenous levels of WAPL; WAPAL at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
细胞定位
[Isoform 2]: Nucleus.; Nucleus. Chromosome. Cytoplasm. Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.
功能
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
