产品名称
COQ6 Rabbit Polyclonal Antibody
蛋白名称
Ubiquinone biosynthesis monooxygenase COQ6 (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51004
Human Swissprot No.
Q9Y2Z9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y2Z9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=217707
Mouse Swissprot No.
Q8R1S0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R1S0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=299195
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q68FU7/entry
特异性
This antibody detects endogenous levels of COQ6 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side . Golgi apparatus . Cell projection . Localizes to cell processes and Golgi apparatus in podocytes. .
功能
FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6 (By similarity). Is able to perform the deamination reaction at C4 of 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) to produce DHHB when expressed in yeast cells lacking COQ9, even if utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals, where only C5 hydroxylation of HHB has been shown .
