产品名称
NSUN5 Rabbit Polyclonal Antibody
基因名称
NSUN5 WBSCR20 WBSCR20A
蛋白名称
Putative methyltransferase NSUN5 (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96P11
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96P11/entry
Mouse Swissprot No.
Q8K4F6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K4F6
免疫原
Synthesized peptide derived from human protein . at AA range: 320-400
特异性
NSUN5 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of an evolutionarily conserved family of proteins that may function as methyltransferases. This gene is located in a larger region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. There are two pseudogenes for this gene located in the same region of chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],
组织表达
Ubiquitous (PubMed:11978965, PubMed:12073013). Detected in placenta, heart and skeletal muscle (PubMed:11978965, PubMed:12073013).
细胞定位
Nucleus, nucleolus .
功能
function:May have S-adenosyl-L-methionine-dependent methyl-transferase activity .,PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the methyltransferase superfamily. RsmB/NOP family.,tissue specificity:Ubiquitous. Detected in placenta, heart and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
