产品名称
Calsequestrin 2 Rabbit Polyclonal Antibody
蛋白名称
Calsequestrin-2 (Calsequestrin, cardiac muscle isoform)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=845
Human Swissprot No.
O14958
Human Swissprot Link
https://www.uniprot.org/uniprot/O14958
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12373
Mouse Swissprot No.
O09161
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O09161/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29209
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P51868/entry
特异性
This antibody detects endogenous levels of Calsequestrin 2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Sarcoplasmic reticulum lumen . This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells. .
功能
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
