产品名称
ADRM1 Rabbit Polyclonal Antibody
蛋白名称
Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11047
Human Swissprot No.
Q16186
Human Swissprot Link
https://www.uniprot.org/uniprot/Q16186
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56436
Mouse Swissprot No.
Q9JKV1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JKV1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65138
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JMB5/entry
特异性
This antibody detects endogenous levels of ADRM1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus .
功能
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins . This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required . Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair . Within the complex, functions as a proteasomal ubiquitin receptor . Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation . UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex .
