产品名称
WDR24 Rabbit Polyclonal Antibody
蛋白名称
WD repeat-containing protein 24
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84219
Human Swissprot No.
Q96S15
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96S15
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=268933
Mouse Swissprot No.
Q8CFJ9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CFJ9/entry
特异性
This antibody detects endogenous levels of WDR24 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway . Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex . It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 . In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux .
