产品名称
PDE4A Rabbit Polyclonal Antibody
蛋白名称
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5141
Human Swissprot No.
P27815
Human Swissprot Link
https://www.uniprot.org/uniprot/P27815
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18577
Mouse Swissprot No.
O89084
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O89084/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25638
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P54748/entry
特异性
This antibody detects endogenous levels of PDE4A at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
[Isoform 1]: Expressed in lymphoid cell subsets including CD8-positive T cells and T-helper 2 cells. Expressed in dendritic cells. ; [Isoform 2]: Highly expressed in liver, stomach, testis, thyroid and adrenal glands and at a lower extent in placenta, kidney, pancreas, ovary, uterus and skin. Expressed in myeloid cell subsets including dendritic cells, monocytes, macrophages, eosinophils and mast cells. Expressed in natural killer cells. Expressed in bronchial smooth muscle. ; [Isoform 6]: Expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. ; [Isoform 7]: Expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Found in specific neuronal subpopulations including cortical pyramidal neurons, horn neurons in the spinal cord and Purkinje cells in cerebellum (at protein level).
细胞定位
[Isoform 1]: Cytoplasm, perinuclear region .; [Isoform 2]: Cytoplasm, perinuclear region . Cell projection, ruffle membrane .; [Isoform 3]: Cytoplasm, cytosol .; [Isoform 4]: Membrane; Peripheral membrane protein . Isoform 4 has propensity for association with membranes. .; [Isoform 6]: Cytoplasm, perinuclear region .; [Isoform 7]: Cytoplasm, cytosol. Membrane; Peripheral membrane protein . Predominantly cytosolic. .
功能
Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. ; [Isoform 1]: Efficiently hydrolyzes cAMP. ; [Isoform 2]: Efficiently hydrolyzes cAMP. ; [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. ; [Isoform 4]: Efficiently hydrolyzes cAMP. ; [Isoform 6]: Efficiently hydrolyzes cAMP. ; [Isoform 7]: Efficiently hydrolyzes cAMP.
