产品名称
Dermatopontin Rabbit Polyclonal Antibody
蛋白名称
Dermatopontin (Tyrosine-rich acidic matrix protein) (TRAMP)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1805
Human Swissprot No.
Q07507
Human Swissprot Link
https://www.uniprot.org/uniprot/Q07507
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56429
Mouse Swissprot No.
Q9QZZ6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QZZ6/entry
特异性
This antibody detects endogenous levels of Dermatopontin at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).
