产品名称
NCKAP1 Rabbit Polyclonal Antibody
基因名称
NCKAP1 HEM2 KIAA0587 NAP1
蛋白名称
Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10787
Human Swissprot No.
Q9Y2A7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y2A7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50884
Mouse Swissprot No.
P28660
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P28660/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58823
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P55161/entry
特异性
This antibody detects endogenous levels of NCKAP1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle. Expressed in cells of various brain regions including Purkinje cells and dentate nucleus of the cerebellum, CA4 region and dentate gyrus of the hippocampus, and in frontal gray and white matter (PubMed:28940097).
细胞定位
Cell membrane ; Single-pass membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Single-pass membrane protein ; Cytoplasmic side . At the interface between the lamellipodial actin meshwork and the membrane. .
功能
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
