产品名称
CXXC5 Rabbit Polyclonal Antibody
基因名称
CXXC5 HSPC195 TCCCIA00297
蛋白名称
CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51523
Human Swissprot No.
Q7LFL8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q7LFL8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67393
Mouse Swissprot No.
Q91WA4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91WA4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=291670
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XIQ3/entry
特异性
This antibody detects endogenous levels of CXXC5 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Cytoplasm . Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. .
功能
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) . May repress COX4I2 transactivation induced by CHCHD2 and RBPJ . Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG .
