产品名称
PAN2 Rabbit Polyclonal Antibody
蛋白名称
PAB-dependent poly(A)-specific ribonuclease subunit 2 (hPan2) (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9924
Human Swissprot No.
Q504Q3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q504Q3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=103135
Mouse Swissprot No.
Q8BGF7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BGF7/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=408200
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6IE70/entry
特异性
This antibody detects endogenous levels of PAN2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Cytoplasm, P-body . Nucleus . Shuttles between nucleus and cytoplasm. .
功能
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
