产品名称
HERP Rabbit Polyclonal Antibody
基因名称
HERPUD1 HERP KIAA0025 MIF1
蛋白名称
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9709
Human Swissprot No.
Q15011
Human Swissprot Link
https://www.uniprot.org/uniprot/Q15011
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64209
Mouse Swissprot No.
Q9JJK5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJK5/entry
特异性
This antibody detects endogenous levels of HERP at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins . Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway .
