产品名称
TWIST2 Rabbit Polyclonal Antibody
基因名称
TWIST2 BHLHA39 DERMO1
蛋白名称
Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117581
Human Swissprot No.
Q8WVJ9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8WVJ9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13345
Mouse Swissprot No.
Q9D030
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D030/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59327
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P97831/entry
特异性
This antibody detects endogenous levels of TWIST2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules.
细胞定位
Nucleus . Cytoplasm . Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
功能
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
