产品名称
SDCCAG3 Rabbit Polyclonal Antibody
蛋白名称
Serologically defined colon cancer antigen 3 (Antigen NY-CO-3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10807
Human Swissprot No.
Q96C92
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96C92
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68112
Mouse Swissprot No.
A2AIW0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A2AIW0/entry
特异性
This antibody detects endogenous levels of SDCCAG3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in the colon (at protein level).
细胞定位
Cytoplasm . Early endosome . Endosome . Recycling endosome . Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body . Colocalizes in a WASHC2-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552). During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes with IFT88 and gamma-tubulin at the basal body of primary cilia (PubMed:27767179). Colocalizes with IFT88 and pericentrin at the centrosome (PubMed:27767179). .
功能
Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis . Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 . Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 . Plays a role in the formation of cilia . Involved in cargo protein localization, such as PKD2, at primary cilia . Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity).
