产品名称
S10A7 Rabbit Polyclonal Antibody
基因名称
S100A7 PSOR1 S100A7C
蛋白名称
Protein S100-A7 (Psoriasin) (S100 calcium-binding protein A7)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P31151
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P31151/entry
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
S10A7 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
S100 calcium binding protein A7(S100A7) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014],
组织表达
Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.
细胞定位
Cytoplasm . Secreted . Secreted by a non-classical secretory pathway.
功能
mass spectrometry: PubMed:8526920,similarity:Belongs to the S-101 family.,similarity:Contains 2 EF-hand domains.,subcellular location:Secreted by a non-classical secretory pathway.,subunit:Interacts with RANBP9.,tissue specificity:Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
