产品名称
ARP2 Rabbit Polyclonal Antibody
蛋白名称
Actin-related protein 2 (Actin-like protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10097
Human Swissprot No.
P61160
Human Swissprot Link
https://www.uniprot.org/uniprot/P61160
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66713
Mouse Swissprot No.
P61161
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P61161/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=289820
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5M7U6/entry
特异性
This antibody detects endogenous levels of ARP2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, cytoskeleton . Cell projection . Nucleus .
功能
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . Seems to contact the pointed end of the daughter actin filament . In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) .
