产品名称
PTPIP51 Rabbit Polyclonal Antibody
基因名称
FAM82A2 FAM82C PTPIP51 hucep-10 UNQ3122/PRO10274
蛋白名称
Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55177
Human Swissprot No.
Q96TC7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96TC7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67809
Mouse Swissprot No.
Q3UJU9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UJU9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=311328
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q66H15/entry
特异性
This antibody detects endogenous levels of PTPIP51 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.
细胞定位
Mitochondrion outer membrane ; Single-pass membrane protein . Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. .
功能
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
