产品名称
WDR1 Rabbit Polyclonal Antibody
蛋白名称
WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9948
Human Swissprot No.
O75083
Human Swissprot Link
https://www.uniprot.org/uniprot/O75083
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22388
Mouse Swissprot No.
O88342
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88342/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360950
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5RKI0/entry
特异性
This antibody detects endogenous levels of WDR1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in peripheral blood mononuclear cells (at protein level).
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, podosome . Cell junction .
功能
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins . Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions . Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt .
