产品名称
OSBPL2 Rabbit Polyclonal Antibody
基因名称
OSBPL2 KIAA0772 ORP2
蛋白名称
Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9885
Human Swissprot No.
Q9H1P3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H1P3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=228983
Mouse Swissprot No.
Q8BX94
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BX94/entry
特异性
This antibody detects endogenous levels of OSBPL2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, cytosol . Lipid droplet . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Detected on the surface of cytosolic lipid droplets (PubMed:19224871). Recruited to the cell membrane by phosphatidylinositol-phosphate binding (PubMed:30581148). .
功能
Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane . Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate . Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate . Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) .
