产品名称
PTGES2 Rabbit Polyclonal Antibody
基因名称
PTGES2 C9orf15 PGES2
蛋白名称
Prostaglandin E synthase 2 (EC 5.3.99.3) (Microsomal prostaglandin E synthase 2) (mPGES-2) [Cleaved into: Prostaglandin E synthase 2 truncated form]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80142
Human Swissprot No.
Q9H7Z7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H7Z7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=96979
Mouse Swissprot No.
Q8BWM0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BWM0/entry
特异性
This antibody detects endogenous levels of PTGES2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.
细胞定位
Golgi apparatus membrane ; Single-pass membrane protein .; [Prostaglandin E synthase 2 truncated form]: Cytoplasm, perinuclear region . Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region. .
功能
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) . The biological function and the GSH-dependent property of PTGES2 is still under debate . In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity).
