产品名称
DHCR24 Rabbit Polyclonal Antibody
蛋白名称
Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1718
Human Swissprot No.
Q15392
Human Swissprot Link
https://www.uniprot.org/uniprot/Q15392
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74754
Mouse Swissprot No.
Q8VCH6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VCH6/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5BQE6/entry
特异性
This antibody detects endogenous levels of DHCR24 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein . Golgi apparatus membrane ; Single-pass membrane protein .
功能
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis . In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress . Also protects against amyloid-beta peptide-induced apoptosis .
