产品名称
ATP1B1 Rabbit Polyclonal Antibody
蛋白名称
Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=481
Human Swissprot No.
P05026
Human Swissprot Link
https://www.uniprot.org/uniprot/P05026
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11931
Mouse Swissprot No.
P14094
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P14094/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25650
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P07340/entry
特异性
This antibody detects endogenous levels of ATP1B1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Found in most tissues.
细胞定位
Cell membrane ; Single-pass type II membrane protein . Apical cell membrane ; Single-pass type II membrane protein . Cell membrane, sarcolemma . Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. .
功能
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane . Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 . ; Involved in cell adhesion and establishing epithelial cell polarity.
