产品名称
Sur-8 Rabbit Polyclonal Antibody
蛋白名称
Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8036
Human Swissprot No.
Q9UQ13
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UQ13
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56392
Mouse Swissprot No.
O88520
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88520/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=309548
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AYI5/entry
特异性
This antibody detects endogenous levels of Sur-8 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus . Translocates from cytoplasm to nucleus upon growth factor stimulation. .
功能
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
