产品名称
TMEM119 Rabbit Polyclonal Antibody
基因名称
TMEM119 PSEC0199 UNQ731/PRO1415
蛋白名称
Transmembrane protein 119
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=338773
Human Swissprot No.
Q4V9L6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q4V9L6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=231633
Mouse Swissprot No.
Q8R138
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R138/entry
特异性
This antibody detects endogenous levels of TMEM119 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Endoplasmic reticulum membrane .
功能
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts . May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).
