产品名称
CORO1C Rabbit Polyclonal Antibody
蛋白名称
Coronin-1C (Coronin-3) (hCRNN4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23603
Human Swissprot No.
Q9ULV4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9ULV4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23790
Mouse Swissprot No.
Q9WUM4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WUM4/entry
特异性
This antibody detects endogenous levels of CORO1C at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium . Cell projection, ruffle membrane . Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Endosome membrane . All isoforms colocalize with the actin cytoskeleton in the cytosol, and especially in the cell cortex (PubMed:10828594, PubMed:19651142, PubMed:25074804). Colocalizes with F-actin at the leading edge of lamellipodia. Partially colocalizes with microtubules and vimentin intermediate filaments (PubMed:10828594, PubMed:19651142, PubMed:25074804). Localizes to endosome membrane tubules/buds (PubMed:30220460). .; [Isoform 3]: Cell membrane, sarcolemma . Cytoplasm, myofibril, sarcomere . Cell junction, synapse . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates. Colocalizes with the actin cytoskeleton in the cytosol, and especially in the cell cortex. .
功能
Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 . Increases the presence of activated RAC1 at the leading edge of migrating cells . Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission . Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane . Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). ; [Isoform 3]: Involved in myogenic differentiation.
