产品名称
CREST Rabbit Polyclonal Antibody
基因名称
SS18L1 CREST KIAA0693
蛋白名称
Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26039
Human Swissprot No.
O75177
Human Swissprot Link
https://www.uniprot.org/uniprot/O75177
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=269397
Mouse Swissprot No.
Q8BW22
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BW22/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=192352
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q91XJ0/entry
特异性
This antibody detects endogenous levels of CREST at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous; with lowest levels in spleen.
细胞定位
Nucleus . Chromosome, centromere, kinetochore . Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). .
功能
Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).
