产品名称
CNOT9 Rabbit Polyclonal Antibody
蛋白名称
Cell differentiation protein RCD1 homolog (Rcd-1) (CCR4-NOT transcription complex subunit 9)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9125
Human Swissprot No.
Q92600
Human Swissprot Link
https://www.uniprot.org/uniprot/Q92600
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58184
Mouse Swissprot No.
Q9JKY0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JKY0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=301513
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5PQL2/entry
特异性
This antibody detects endogenous levels of CNOT9 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in spleen, thymus, prostate, testis, ovary and intestine.
细胞定位
Nucleus . Cytoplasm, P-body . NANOS2 promotes its localization to P-body. .
功能
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
