产品名称
HAX1 Rabbit Polyclonal Antibody
蛋白名称
HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10456
Human Swissprot No.
O00165
Human Swissprot Link
https://www.uniprot.org/uniprot/O00165
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23897
Mouse Swissprot No.
O35387
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35387/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=291202
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TSE9/entry
特异性
This antibody detects endogenous levels of HAX1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Up-regulated in oral cancers.
细胞定位
Mitochondrion . Endoplasmic reticulum . Nucleus membrane . Cytoplasmic vesicle . Cytoplasm, cell cortex . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Sarcoplasmic reticulum . Cytoplasm, P-body .; [Isoform 1]: Cytoplasm . Nucleus . Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited, and in response to cellular stress caused by arsenite (in vitro). .; [Isoform 3]: Cytoplasm . Nucleus . Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro). .; [Isoform 4]: Cytoplasm . Nucleus . Shuttles between nucleus and cytoplasm. .; [Isoform 5]: Cytoplasm . Predominantly cytoplasmic. .
功能
Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex . Slows down the rate of inactivation of KCNC3 channels . Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
