产品名称
MICAL2 Rabbit Polyclonal Antibody
基因名称
MICAL2 KIAA0750 MICAL2PV1 MICAL2PV2
蛋白名称
Protein-methionine sulfoxide oxidase MICAL2 (EC 1.14.13.-) (Molecule interacting with CasL protein 2) (MICAL-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9645
Human Swissprot No.
O94851
Human Swissprot Link
https://www.uniprot.org/uniprot/O94851
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=320878
Mouse Swissprot No.
Q8BML1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BML1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=365352
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/D4A1F2/entry
特异性
This antibody detects endogenous levels of MICAL2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Cytoplasm .
功能
Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization . Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network . Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA .
