产品名称
PDLIM7 Rabbit Polyclonal Antibody
蛋白名称
PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9260
Human Swissprot No.
Q9NR12
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NR12
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67399
Mouse Swissprot No.
Q3TJD7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TJD7/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=286908
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z1Z9/entry
特异性
This antibody detects endogenous levels of PDLIM7 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 1 and isoform 2 are expressed ubiquitously, however, isoform 2 predominates in skeletal muscle, isoform 1 is more abundant in lung, spleen, leukocytes and fetal liver.
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Colocalizes with TBX4 and TBX5 to actin filaments (By similarity). .
功能
May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity).
